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Learn about AMRIX® (Cyclobenzaprine Hydrochloride Extended‐Release Capsules) for the treatment of muscle spasm due to acute, painful musculoskeletal conditions. AMRIX is a prescription medicine used along with rest and physical therapy to help treat muscle spasm due to acute, painful musculoskeletal problems. AMRIX should only be used for up to 2 or 3 weeks. It is not known if AMRIX is effective when used for longer periods. It is not known if AMRIX is safe and effective in children. Do not take AMRIX if you: • are allergic to cyclobenzaprine or any of the components of AMRIX. Talk to your healthcare provider or get medical help right away if you have symptoms of an allergic reaction such as difficulty breathing, hives, swelling of your face or tongue, or itching • are taking certain antidepressants known as monoamine oxidase (MAO) inhibitors, or it has been 14 days or less since you stopped taking a MAO inhibitor. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure • have had a recent heart attack • have heart rhythm problems (arrhythmias) • have heart failure • have an overactive thyroid (hyperthyroidism). Talk to your healthcare provider before taking this medicine if you have any of the conditions listed above. You should not drink alcohol until you know how AMRIX affects you. Taking AMRIX with alcohol or other medicines that depress your central nervous system can slow your thinking and physical response times. Do not drive, operate machinery, or do other dangerous activities until you know how AMRIX affects you. AMRIX may cause serious side effects that may lead to heart attack or stroke. Call your healthcare provider immediately or go to the nearest hospital emergency room if you have: • irregular or abnormal heartbeats (arrhythmias) • fast heartbeat (tachycardia). Serotonin syndrome is a serious medical condition that may happen when AMRIX is taken with certain other medicines. Call your healthcare provider right away or go to the nearest hospital emergency room if you become severely ill and have some or all of these symptoms: • agitation, hallucinations, coma, or other changes in mental status • coordination problems or muscle twitching (overactive reflexes) • fast heartbeat, high or low blood pressure • sweating or fever • nausea, vomiting, or diarrhea • muscle stiffness or tightness. The most common side effects of AMRIX include dry mouth, dizziness, fatigue, constipation, nausea, upset stomach, and drowsiness. Tell your healthcare provider if you get any side effect that bothers you or that does not go away. These are not all the possible side effects of AMRIX. For more information, talk to your healthcare provider or pharmacist. Please see the Patient Information Leaflet within the accompanying Full Prescribing Information.

More Information on Allergic Reaction Symptoms Due to Food or Dog & Much More. Learn More About Allergic Reaction Symptoms in Babies.

Learn about common food allergies, symptoms of an allergic reaction and how to diagnose and treat food allergies.

Learn more about Activase® (Alteplase) for Acute Ischemic Stroke Treatment. Indications Activase (alteplase) is indicated for the treatment of acute ischemic stroke. Exclude intracranial hemorrhage as the primary cause of stroke signs and symptoms prior to initiation of treatment. Initiate treatment as soon as possible but within 3 hours after symptom onset. Activase is indicated for use in acute myocardial infarction (AMI) for the reduction of mortality and reduction of the incidence of heart failure. Limitation of Use: The risk of stroke may outweigh the benefit produced by thrombolytic therapy in patients whose AMI puts them at low risk for death or heart failure. Activase is indicated for the lysis of acute massive pulmonary embolism (PE), defined as: • Acute pulmonary emboli obstructing blood flow to a lobe or multiple lung segments. • Acute pulmonary emboli accompanied by unstable hemodynamics, e.g.,failure to maintain blood pressure without supportive measures. Important Safety Information Contraindications Do not administer Activase to treat acute ischemic stroke in the following situations in which the risk of bleeding is greater than the potential benefit: current intracranial hemorrhage (ICH); subarachnoid hemorrhage; active internal bleeding; recent (within 3months) intracranial or intraspinal surgery or serious head trauma; presence of intracranial conditions that may increase the risk of bleeding; bleeding diathesis; and current severe uncontrolled hypertension. Do not administer Activase to treat acute myocardial infarction or pulmonary embolism in the following situations in which the risk of bleeding is greater than the potential benefit: active internal bleeding; history of recent stroke; recent (within 3months) intracranial or intraspinal surgery or serious head trauma; presence of intracranial conditions that may increase the risk of bleeding; bleeding diathesis; and current severe uncontrolled hypertension. Warnings and Precautions Bleeding Activase can cause significant, sometimes fatal, internal or external bleeding, especially at arterial and venous puncture sites.Avoid intramuscular injections and trauma to the patient. Fatal cases of hemorrhage associated with traumatic intubation in patients administered Activase have been reported. Heparin, aspirin, or Activase may cause bleeding complications; therefore carefully monitor for bleeding. If serious bleeding occurs, terminate the Activase infusion. Orolingual Angioedema Monitor patients during and for several hours after infusion for orolingual angioedema. If angioedema develops, discontinue the Activase infusion and promptly institute appropriate therapy. Cholesterol Embolization Cholesterol embolism, sometimes fatal, has been reported rarely in patients treated with thrombolytic agents. Reembolization of Deep Venous Thrombi during Treatment for Acute Massive Pulmonary Embolism Consider the possible risk of reembolization due to the lysis of underlying deep venous thrombi patients with acute massive PE Coagulation Tests May be Unreliable during Activase Therapy Coagulation tests and/or measures of fibrinolytic activity may be unreliable during Activase therapy. Adverse Reactions The most frequent adverse reaction associated with Activase therapy is bleeding. Allergic‑type reactions, e.g.,anaphylactoid reaction, laryngeal edema, orolingual angioedema, rash, and urticaria have been reported.

Rhode Island Asthma & Allergy Specialists diagnose and treat allergy related problems like asthma, allergic reaction to antibiotics. We help you defeat your symptoms.